Cannabis and Prescription Medications: Understanding Potential Risks and Interaction

Cannabis use can significantly impact the effectiveness and safety of various prescription medications. Both tetrahydrocannabinol (THC) and cannabidiol (CBD), the primary compounds in cannabis, have been shown to interact with key liver enzymes responsible for drug metabolism, such as cytochrome P450 (CYP) isoenzymes. For instance, CBD has been reported to interfere with immunosuppressant drugs like cyclosporine and tacrolimus, potentially leading to increased serum levels and toxic adverse effects.

Additionally, cannabis can alter the metabolism of medications such as warfarin, leading to an increased risk of bleeding. Smoking cannabis has also been shown to increase the metabolism of drugs like theophylline and chlorpromazine, resulting in reduced plasma concentrations. Given these potential interactions, it is crucial for patients to consult healthcare providers before combining cannabis with prescription medications to ensure safety and therapeutic efficacy.

For more information, visit Pharmacy Times.